[BioC] mean versus linear model?

Simon Melov smelov at buckinstitute.org
Mon Jan 12 03:21:00 MET 2004


Not being a statistician, I was wondering if there were a 
straightforward answer as to why using a linear model was "better" than 
a straight mean in limma when estimating the average M value across 
multiple chips. I believe that the regression analysis is supposed to 
be less influenced by outliers, is this the chief reason the linear 
model is implemented?

thanks

Simon.



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