[R-meta] multilevel glmm meta-analysis question
kzc0061 @end|ng |rom @uburn@edu
Tue Mar 2 20:30:18 CET 2021
I am undertaking a multilevel generalized linear mixed model meta-analysis and, following the advice here<http://www.metafor-project.org/doku.php/todo> regarding multilevel glmms in metafor, I am using the glmer function of the lme4 package. I am wondering 1) if that I am specifying my weights correctly and 2) how to get values that are important to report for this meta-analysis, like heterogeneity.
In this meta-analysis, I hypothesize that both socioeconomic and ecological variables are important in predicting parasite prevalence in free-roaming cats and dogs-- so I'm mainly interested in the effects of moderators (an average prevalence isn't very informative). Since each study gives a proportion of dogs/cats infected out of a total, I have chosen a binomial model.
Here is my code for one of my univariable models:
res_san_3<-glmer(prevalence ~ san_10 + (1 | Species) + (1 | country) + (1 | study) + (1 | uniq), weights = 1/vi, data=feral, family=binomial, na.action=na.fail)
prevalence is the total infected out of the total sampled dogs/cats of each study, and each listed random effect there are the different nested levels. Nested levels include species of parasite, followed by country, then study, then each sample within each study (because many studies sampled multiple parasites). I used inverse variance for the weights here.
I would greatly appreciate any thoughts, or any helpful information that could be referred to me. I've searched the web extensively for help understanding multilevel glmms and was unable to find answers to my questions.
Thank you so much,
Below here is the output from that model in case it is helpful:
Generalized linear mixed model fit by maximum likelihood (Laplace Approximation) ['glmerMod']
Family: binomial ( logit )
Formula: prevalence ~ san_10 + (1 | Species) + (1 | country) + (1 | study) + (1 | uniq)
AIC BIC logLik deviance df.resid
5131.5 5162.8 -2559.7 5119.5 1374
Min 1Q Median 3Q Max
-1.3271 -0.4905 -0.2745 0.1395 1.8286
Groups Name Variance Std.Dev.
uniq (Intercept) 0.650879 0.80677
study (Intercept) 0.386573 0.62175
Species (Intercept) 0.245294 0.49527
country (Intercept) 0.007934 0.08907
Number of obs: 1380, groups: uniq, 1380; study, 449; Species, 204; country, 70
Estimate Std. Error z value Pr(>|z|)
(Intercept) -0.49574 0.29256 -1.694 0.090176 .
san_10 -0.11641 0.03191 -3.648 0.000264 ***
Signif. codes: 0 �***� 0.001 �**� 0.01 �*� 0.05 �.� 0.1 � � 1
Kayleigh Chalkowski, M.Sc.
Fulbright Madagascar 2020-2021
School of Forestry and Wildlife Sciences
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