[R-meta] Asymmetric CI for certain estimates in a meta-analysis
@m@r|n23 @end|ng |rom u|c@edu
Sun Jun 20 22:24:42 CEST 2021
I have a question related to using estimated effects with asymmetric
confidence intervals in a meta-analysis.
In our study, we have extracted 26 estimates and confidence intervals. For
a few of the extractions, the confidence intervals are asymmetric for for
the following reasons: (1) the CIs are bootstrapped and (2) the outcome is
a ratio of ratios. My understanding is that both fixed and random effects
models assume the estimates follow a standard normal distribution and that
the "meta" package in R uses the extracted CIs to estimate SEs and then
re-calculates symmetric confidence intervals.
Is there anything we can do to account for the fact that some of our
estimates have asymmetric confidence intervals or do we need to report this
issue as a limitation of our study?
Thank you in advance for your help!
*Samantha Marinello*, MS
Division of Health Policy & Administration
School of Public Health
University of Illinois at Chicago
1603 W. Taylor Street
Chicago, IL 60612
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