[R-meta] ES and meta-analysis for single-case studies

James Pustejovsky jepu@to @end|ng |rom gm@||@com
Wed Jul 21 16:11:53 CEST 2021

Hi Filippo,

Your question requires making judgements about the strengths and
limitations of evidence from these single-case-control designs relative to
the evidence from classical control-patient comparisons. Without
understanding the substance of the studies you're looking at, I am not in a
position to advise about this.

That said, one strategy that meta-analysts often use in these sorts of
situations is to investigate design differences empirically. That is: go
ahead and calculate effect size estimates across both types of designs,
then use sub-group analysis (or meta-regression) to look at differences in
the distribution of effects between the two types of study designs.


On Tue, Jul 20, 2021 at 11:09 AM Filippo Gambarota <
filippo.gambarota using gmail.com> wrote:

> Hello!
> I would like to perform a meta-analysis where a lot of studies report a
> single-subject analysis compared to a control group (this is very common in
> neuropsychological literature). I've found some literature
> (e.g., Crawford-Howell, 1998) where t-test and the respective effect size
> are proposed for that kind of analysis, however I'm not totally sure if
> it's possible to compare classical control-patients studies with this
> case-control design. Do you have some suggestions?
> Thanks!
> Filippo
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