[R-meta] ES and meta-analysis for single-case studies

Filippo Gambarota ||||ppo@g@mb@rot@ @end|ng |rom gm@||@com
Wed Jul 21 16:40:03 CEST 2021

Thank you James, that's a great suggestion. Basically my main doubt was
about calculating appropriate effect size and variance for that specific
situation. Of course, putting in the same meta-analysis very different
research design could be very complicated. For example, Crawford et al.
(2010; COGNITIVE NEUROPSYCHOLOGY) proposed a measure called Zcc as
effect size index but for me does not make sense for a meta-analytic
approach. Is basically a one-sample cohen's d where the population mean is
the single subject and the group mean is the controls mean. I don't know if
it is possible to calculate an appropriate effect size in that situation.


On Wed, 21 Jul 2021 at 17:12, James Pustejovsky <jepusto using gmail.com> wrote:

> Hi Filippo,
> Your question requires making judgements about the strengths and
> limitations of evidence from these single-case-control designs relative to
> the evidence from classical control-patient comparisons. Without
> understanding the substance of the studies you're looking at, I am not in a
> position to advise about this.
> That said, one strategy that meta-analysts often use in these sorts of
> situations is to investigate design differences empirically. That is: go
> ahead and calculate effect size estimates across both types of designs,
> then use sub-group analysis (or meta-regression) to look at differences in
> the distribution of effects between the two types of study designs.
> James
> On Tue, Jul 20, 2021 at 11:09 AM Filippo Gambarota <
> filippo.gambarota using gmail.com> wrote:
>> Hello!
>> I would like to perform a meta-analysis where a lot of studies report a
>> single-subject analysis compared to a control group (this is very common
>> in
>> neuropsychological literature). I've found some literature
>> (e.g., Crawford-Howell, 1998) where t-test and the respective effect size
>> are proposed for that kind of analysis, however I'm not totally sure if
>> it's possible to compare classical control-patients studies with this
>> case-control design. Do you have some suggestions?
>> Thanks!
>> Filippo
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*Filippo Gambarota*
PhD Student - University of Padova
Department of Developmental and Social Psychology
Website: filippogambarota.netlify.app
Research Group: Colab <http://colab.psy.unipd.it/>   Psicostat

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