[R-meta] I have any problems with meta-analysis of proportions
Michael Dewey
||@t@ @end|ng |rom dewey@myzen@co@uk
Tue Apr 6 10:48:25 CEST 2021
Comments in-line
On 05/04/2021 17:32, Martin Lobo wrote:
> Hi everyone,
>
> I performed a systematic review on the persistence of some drugs.
> I found 30 randomized clinical trials and 10 observational studies.
> Although I understand that they should not be meta analyzed together (I should stratify them or analyze them separately), Actually, of the RCTs, I only use the active drug arm, so I think that by breaking the branching, maybe I could take all the data as observational.
Yes, you now have a set of observational studies if you only take one
arm from the trials.
> Is this correct ?
> If so, how do I describe the methodological part, what guidelines and quality scales should I use (PRISMA, STROBE, COCHRANE, NOS, JADAD?).
>
It is still a meta-analysis so use PRISMA
> On the other hand, I have never performed meta-analysis of proportions, and I am having too much heterogeneity I2 97%. How could I control this? The studies are of good quality. I use the metaprop function.
>
In a meta-analysis of observational studies high heterogeneity is almost
ineitable.
> Than's
>
>
>
>
> Lorenzo Mart�n Lobo MTSAC, FACC, FESC
> Especialista Jerarquizado en Cardiolog�a
> Jefe de Dpto Enf. Cardiovasculares y Cardiometabolismo Hospital Militar Campo de Mayo.
> Jefe de Cardiolog�a Hospital Militar Campo de Mayo
> Ex Jefe de Unidad Coronaria Hospital Militar Campo de Mayo
> Miembro Titular de la Sociedad Argentina de Cardiolog�a
> Fellow American College of Cardiology
> Fellow European Society of Cardiology
> Ex Miembro del Area de Investigaci�n de la SAC
> Ex Director del Consejo de Aterosclerosis y Trombosis de la SAC
> Miembro Asesor del Consejo de Aterosclerosis y Trombosis de la SAC
> Ex Director del Consejo de Epidemiolog�a y Prevenci�n Cardiovascular de la SAC
>
> Miembro Asesor del Consejo de Epidemiolog�a y Prevenci�n Cardiovascular de la SAC
>
>
> Experto en Lipidos de la Sociedad Argentina de Lipidos.
> Miembro de la Sociedad Argentina de Lipidos.
> Instructor de ACLS de la American Heart Association
>
>
> ________________________________
> De: R-sig-meta-analysis <r-sig-meta-analysis-bounces using r-project.org> en nombre de r-sig-meta-analysis-request using r-project.org <r-sig-meta-analysis-request using r-project.org>
> Enviado: s�bado, 31 de octubre de 2020 08:05
> Para: r-sig-meta-analysis using r-project.org <r-sig-meta-analysis using r-project.org>
> Asunto: R-sig-meta-analysis Digest, Vol 41, Issue 19
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> 1. Re: GOSH plots for multi-level meta (rma.mv) (Hellen Mirr)
>
> ----------------------------------------------------------------------
>
> Message: 1
> Date: Fri, 30 Oct 2020 13:03:34 +0000
> From: Hellen Mirr <hellenmir554 using gmail.com>
> To: "Viechtbauer, Wolfgang (SP)"
> <wolfgang.viechtbauer using maastrichtuniversity.nl>
> Cc: "r-sig-meta-analysis using r-project.org"
> <r-sig-meta-analysis using r-project.org>
> Subject: Re: [R-meta] GOSH plots for multi-level meta (rma.mv)
> Message-ID:
> <CAF6nRJqkgQ4_vkF0sdf=_anW2Etp2snB14F-v0ot8rZ9JFaXGQ using mail.gmail.com>
> Content-Type: text/plain; charset="utf-8"
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> Dear Wolfgang,
>
> Thank you very much for your clear explanation.
>
> Best,
> Hellen
>
> On Fri, Oct 30, 2020 at 11:48 AM Viechtbauer, Wolfgang (SP) <
> wolfgang.viechtbauer using maastrichtuniversity.nl> wrote:
>
>> Dear Hellen,
>>
>> This is currently not implemented in metafor. In principle, the idea of a
>> GOSH plot does generalize to more complex models although one needs to
>> think about whether one would want to create subsets based on the indiviual
>> estimates or based on some higher-level grouping variable. For example,
>> suppose we have a multilevel structure such as:
>>
>> study esid yi vi
>> ------------------
>> 1 1 . .
>> 1 2 . .
>> 2 1 . .
>> 3 1 . .
>> 3 2 . .
>> 3 3 . .
>> 4 1 . .
>>
>> So, what are, for example, then the subsets of size 2? Are they based just
>> on the rows? Then the estimates in row 1 and 2 would be one such subset. Or
>> does one base the subsets on the studies? Then rows 1, 2, 3 (i.e., studies
>> 1 and 2) would be such a subset.
>>
>> This could all be implemented (just like cooks.distance() and rstudent()
>> allow for the optional specification of a clustering variable), but I
>> haven't done this.
>>
>> Aside from that: Fitting rma.mv models can take a bit of time. Doing this
>> 1000's of times (based on all possible subsets) could take a LONG time.
>>
>> Best,
>> Wolfgang
>>
>>> -----Original Message-----
>>> From: R-sig-meta-analysis [mailto:
>> r-sig-meta-analysis-bounces using r-project.org]
>>> On Behalf Of Hellen Mirr
>>> Sent: Friday, 30 October, 2020 12:12
>>> To: r-sig-meta-analysis using r-project.org
>>> Subject: [R-meta] GOSH plots for multi-level meta (rma.mv)
>>>
>>> Hello,
>>>
>>> Apologies if this has already been answered, as I could not find any
>>> threads on it.
>>> I was wondering whether it is possible to create a GOSH plot for a
>>> multi-level meta analysis that is an rma.mv object, and how I would go
>>> about that.
>>>
> [[elided Hotmail spam]]
>>>
>>> Best wishes
>>> Hellen
>>
>
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--
Michael
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