[R-meta] I have any problems with meta-analysis of proportions

Martin Lobo m|obo4370 @end|ng |rom hotm@||@com
Mon Apr 5 18:32:29 CEST 2021 

Hi everyone,

I performed  a systematic review on the persistence of some drugs.
I found 30 randomized clinical trials and 10 observational studies.
Although I understand that they should not be meta analyzed together (I should stratify them or analyze them separately), Actually, of the RCTs, I only use the active drug arm, so I think that by breaking the branching, maybe I could take all the data as observational.
Is this correct ?
If so, how do I describe the methodological part, what guidelines and quality scales should I use (PRISMA, STROBE, COCHRANE, NOS, JADAD?).

On the other hand, I have never performed meta-analysis of proportions, and I am having too much heterogeneity I2 97%. How could I control this? The studies are of good quality. I use the metaprop function.

Than's




Lorenzo Mart�n Lobo MTSAC, FACC, FESC
Especialista Jerarquizado en Cardiolog�a
Jefe de Dpto Enf. Cardiovasculares y Cardiometabolismo Hospital Militar Campo de Mayo.
Jefe de Cardiolog�a Hospital Militar Campo de Mayo
Ex Jefe de Unidad Coronaria Hospital Militar Campo de Mayo
Miembro Titular de la Sociedad Argentina de Cardiolog�a
Fellow American College of Cardiology
Fellow European Society of Cardiology
Ex Miembro del Area de Investigaci�n de la SAC
Ex Director del Consejo de Aterosclerosis y Trombosis de la SAC
Miembro Asesor del Consejo de Aterosclerosis y Trombosis de la SAC
Ex Director del Consejo de Epidemiolog�a y Prevenci�n Cardiovascular de la SAC

Miembro Asesor del Consejo de Epidemiolog�a y Prevenci�n Cardiovascular de la SAC


Experto en Lipidos de la Sociedad Argentina de Lipidos.
Miembro de la Sociedad Argentina de Lipidos.
Instructor de ACLS de la American Heart Association


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De: R-sig-meta-analysis <r-sig-meta-analysis-bounces using r-project.org> en nombre de r-sig-meta-analysis-request using r-project.org <r-sig-meta-analysis-request using r-project.org>
Enviado: s�bado, 31 de octubre de 2020 08:05
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Asunto: R-sig-meta-analysis Digest, Vol 41, Issue 19

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Today's Topics:

   1. Re: GOSH plots for multi-level meta (rma.mv) (Hellen Mirr)

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Message: 1
Date: Fri, 30 Oct 2020 13:03:34 +0000
From: Hellen Mirr <hellenmir554 using gmail.com>
To: "Viechtbauer, Wolfgang (SP)"
        <wolfgang.viechtbauer using maastrichtuniversity.nl>
Cc: "r-sig-meta-analysis using r-project.org"
        <r-sig-meta-analysis using r-project.org>
Subject: Re: [R-meta] GOSH plots for multi-level meta (rma.mv)
Message-ID:
        <CAF6nRJqkgQ4_vkF0sdf=_anW2Etp2snB14F-v0ot8rZ9JFaXGQ using mail.gmail.com>
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Dear Wolfgang,

Thank you very much for your clear explanation.

Best,
Hellen

On Fri, Oct 30, 2020 at 11:48 AM Viechtbauer, Wolfgang (SP) <
wolfgang.viechtbauer using maastrichtuniversity.nl> wrote:

> Dear Hellen,
>
> This is currently not implemented in metafor. In principle, the idea of a
> GOSH plot does generalize to more complex models although one needs to
> think about whether one would want to create subsets based on the indiviual
> estimates or based on some higher-level grouping variable. For example,
> suppose we have a multilevel structure such as:
>
> study  esid  yi vi
> ------------------
> 1      1     .  .
> 1      2     .  .
> 2      1     .  .
> 3      1     .  .
> 3      2     .  .
> 3      3     .  .
> 4      1     .  .
>
> So, what are, for example, then the subsets of size 2? Are they based just
> on the rows? Then the estimates in row 1 and 2 would be one such subset. Or
> does one base the subsets on the studies? Then rows 1, 2, 3 (i.e., studies
> 1 and 2) would be such a subset.
>
> This could all be implemented (just like cooks.distance() and rstudent()
> allow for the optional specification of a clustering variable), but I
> haven't done this.
>
> Aside from that: Fitting rma.mv models can take a bit of time. Doing this
> 1000's of times (based on all possible subsets) could take a LONG time.
>
> Best,
> Wolfgang
>
> >-----Original Message-----
> >From: R-sig-meta-analysis [mailto:
> r-sig-meta-analysis-bounces using r-project.org]
> >On Behalf Of Hellen Mirr
> >Sent: Friday, 30 October, 2020 12:12
> >To: r-sig-meta-analysis using r-project.org
> >Subject: [R-meta] GOSH plots for multi-level meta (rma.mv)
> >
> >Hello,
> >
> >Apologies if this has already been answered, as I could not find any
> >threads on it.
> >I was wondering whether it is possible to create a GOSH plot for a
> >multi-level meta analysis that is an rma.mv object, and how I would go
> >about that.
> >
[[elided Hotmail spam]]
> >
> >Best wishes
> >Hellen
>

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