[R-meta] I have any problems with meta-analysis of proportions

Thu Apr 8 18:15:12 CEST 2021

thank you all, you have clarified a lot for me.
some clarifications for you

Michael,
 In this quiestion:
If so, how do I describe the methodological part, what guidelines and quality scales should I use (PRISMA, STROBE, COCHRANE, NOS, JADAD?).

I have read that for meta analysis of observational studies the STROBE guide should be used. Is it the same to use the PRISMA gui as the STROBE in this type of meta analysis?

Lukasz,

In some of my examples the I2 is 97%, T2 (square tau)0.06 (0 <0.01), in this case how would you consider heterogenicity?
the proportion estimates vary from 0.28 to 0.59.

Thank's for your help

Regards

Lorenzo Martín Lobo MTSAC, FACC, FESC
Especialista Jerarquizado en Cardiología
Jefe de Dpto Enf. Cardiovasculares y Cardiometabolismo Hospital Militar Campo de Mayo.
Jefe de Cardiología Hospital Militar Campo de Mayo
Ex Jefe de Unidad Coronaria Hospital Militar Campo de Mayo
Miembro Titular de la Sociedad Argentina de Cardiología
Fellow American College of Cardiology
Fellow European Society of Cardiology
Ex Miembro del Area de Investigación de la SAC
Ex Director del Consejo de Aterosclerosis y Trombosis de la SAC
Miembro Asesor del Consejo de Aterosclerosis y Trombosis de la SAC
Ex Director del Consejo de Epidemiología y Prevención Cardiovascular de la SAC

Miembro Asesor del Consejo de Epidemiología y Prevención Cardiovascular de la SAC

Experto en Lipidos de la Sociedad Argentina de Lipidos.
Miembro de la Sociedad Argentina de Lipidos.
Instructor de ACLS de la American Heart Association

________________________________
De: Michael Dewey <lists using dewey.myzen.co.uk>
Enviado: martes, 6 de abril de 2021 05:48
Para: Martin Lobo <mlobo4370 using hotmail.com>; r-sig-meta-analysis using r-project.org <r-sig-meta-analysis using r-project.org>
Asunto: Re: [R-meta] I have any problems with meta-analysis of proportions

Comments in-line

On 05/04/2021 17:32, Martin Lobo wrote:
> Hi everyone,
>
> I performed  a systematic review on the persistence of some drugs.
> I found 30 randomized clinical trials and 10 observational studies.
> Although I understand that they should not be meta analyzed together (I should stratify them or analyze them separately), Actually, of the RCTs, I only use the active drug arm, so I think that by breaking the branching, maybe I could take all the data as observational.

Yes, you now have a set of observational studies if you only take one
arm from the trials.

> Is this correct ?
> If so, how do I describe the methodological part, what guidelines and quality scales should I use (PRISMA, STROBE, COCHRANE, NOS, JADAD?).
>

It is still a meta-analysis so use PRISMA

> On the other hand, I have never performed meta-analysis of proportions, and I am having too much heterogeneity I2 97%. How could I control this? The studies are of good quality. I use the metaprop function.
>

In a meta-analysis of observational studies high heterogeneity is almost
ineitable.

> Than's
>
>
>
>
> Lorenzo Mart�n Lobo MTSAC, FACC, FESC
> Especialista Jerarquizado en Cardiolog�a
> Jefe de Dpto Enf. Cardiovasculares y Cardiometabolismo Hospital Militar Campo de Mayo.
> Jefe de Cardiolog�a Hospital Militar Campo de Mayo
> Ex Jefe de Unidad Coronaria Hospital Militar Campo de Mayo
> Miembro Titular de la Sociedad Argentina de Cardiolog�a
> Fellow American College of Cardiology
> Fellow European Society of Cardiology
> Ex Miembro del Area de Investigaci�n de la SAC
> Ex Director del Consejo de Aterosclerosis y Trombosis de la SAC
> Miembro Asesor del Consejo de Aterosclerosis y Trombosis de la SAC
> Ex Director del Consejo de Epidemiolog�a y Prevenci�n Cardiovascular de la SAC
>
> Miembro Asesor del Consejo de Epidemiolog�a y Prevenci�n Cardiovascular de la SAC
>
>
> Experto en Lipidos de la Sociedad Argentina de Lipidos.
> Miembro de la Sociedad Argentina de Lipidos.
> Instructor de ACLS de la American Heart Association
>
>
> ________________________________
> De: R-sig-meta-analysis <r-sig-meta-analysis-bounces using r-project.org> en nombre de r-sig-meta-analysis-request using r-project.org <r-sig-meta-analysis-request using r-project.org>
> Enviado: s�bado, 31 de octubre de 2020 08:05
> Para: r-sig-meta-analysis using r-project.org <r-sig-meta-analysis using r-project.org>
> Asunto: R-sig-meta-analysis Digest, Vol 41, Issue 19
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>     1. Re: GOSH plots for multi-level meta (rma.mv) (Hellen Mirr)
>
> ----------------------------------------------------------------------
>
> Message: 1
> Date: Fri, 30 Oct 2020 13:03:34 +0000
> From: Hellen Mirr <hellenmir554 using gmail.com>
> To: "Viechtbauer, Wolfgang (SP)"
>          <wolfgang.viechtbauer using maastrichtuniversity.nl>
> Cc: "r-sig-meta-analysis using r-project.org"
>          <r-sig-meta-analysis using r-project.org>
> Subject: Re: [R-meta] GOSH plots for multi-level meta (rma.mv)
> Message-ID:
>          <CAF6nRJqkgQ4_vkF0sdf=_anW2Etp2snB14F-v0ot8rZ9JFaXGQ using mail.gmail.com>
> Content-Type: text/plain; charset="utf-8"
>
> Dear Wolfgang,
>
> Thank you very much for your clear explanation.
>
> Best,
> Hellen
>
> On Fri, Oct 30, 2020 at 11:48 AM Viechtbauer, Wolfgang (SP) <
> wolfgang.viechtbauer using maastrichtuniversity.nl> wrote:
>
>> Dear Hellen,
>>
>> This is currently not implemented in metafor. In principle, the idea of a
>> GOSH plot does generalize to more complex models although one needs to
>> think about whether one would want to create subsets based on the indiviual
>> estimates or based on some higher-level grouping variable. For example,
>> suppose we have a multilevel structure such as:
>>
>> study  esid  yi vi
>> ------------------
>> 1      1     .  .
>> 1      2     .  .
>> 2      1     .  .
>> 3      1     .  .
>> 3      2     .  .
>> 3      3     .  .
>> 4      1     .  .
>>
>> So, what are, for example, then the subsets of size 2? Are they based just
>> on the rows? Then the estimates in row 1 and 2 would be one such subset. Or
>> does one base the subsets on the studies? Then rows 1, 2, 3 (i.e., studies
>> 1 and 2) would be such a subset.
>>
>> This could all be implemented (just like cooks.distance() and rstudent()
>> allow for the optional specification of a clustering variable), but I
>> haven't done this.
>>
>> Aside from that: Fitting rma.mv models can take a bit of time. Doing this
>> 1000's of times (based on all possible subsets) could take a LONG time.
>>
>> Best,
>> Wolfgang
>>
>>> -----Original Message-----
>>> From: R-sig-meta-analysis [mailto:
>> r-sig-meta-analysis-bounces using r-project.org]
>>> On Behalf Of Hellen Mirr
>>> Sent: Friday, 30 October, 2020 12:12
>>> To: r-sig-meta-analysis using r-project.org
>>> Subject: [R-meta] GOSH plots for multi-level meta (rma.mv)
>>>
>>> Hello,
>>>
>>> Apologies if this has already been answered, as I could not find any
>>> threads on it.
>>> I was wondering whether it is possible to create a GOSH plot for a
>>> multi-level meta analysis that is an rma.mv object, and how I would go
>>> about that.
>>>
> [[elided Hotmail spam]]
>>>
>>> Best wishes
>>> Hellen
>>
>
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--
Michael
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