[R-meta] help with meta-analysis

Nadine Vogt nvogt at uoguelph.ca
Sun Oct 22 15:01:41 CEST 2017

Hi everyone,

I am new to meta-analysis and relatively new to R, and am hoping for some advice regarding a meta-analysis! We are interested in the ability of a vaccine to reduce clinical signs in dogs, and used a dichotomous outcome to characterize the presence/absence of clinical signs in vaccinated and non-vaccinated dogs.

I am currently using a rma.mv model to account for clustering by trials which use the same control group for multiple treatment groups. I recently stumbled across the paper by Ruecker et al. 2017 (http://onlinelibrary.wiley.com/doi/10.1002/jrsm.1259/abstract) and am now wondering if I should be making an adjustment for the use of the same control group using one of those methods as opposed to using clustering methods?

I've attached my dataset and code.

If the rma.mv model is appropriate, I just want to confirm that the studies with 0 events in both arms should be included. I am also wondering how the weights for the studies are calculated in rma.mv, and whether I need to adjust them for the studies with 0 events (although it seems to already do this, by assigning relatively low weights)?

Thanks in advance!

Nadine Vogt

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