Trial	Authors	Vaccine_type	Vaccine_class	Vaccine_class_two	Dose of vaccine	Age of dogs	Age_class	immunosuppression	Needle vs. ticks	Commercially_available	Commercial name	lameness_cases_vax	anorexia_cases_vax	pyrexia_cases_vax	depression_cases_vax	total_vax	lameness_cases_ctrl	anorexia_cases_ctrl	pyrexia_cases_ctrl	depression_cases_ctrl	total_ctrl	Cluster_no	Cluster_author
1	Chu et al. 1992a	bacterin	bacterin	bacterin	1ml 	<18 months	adult	yes	needle	yes	LymeVax/Duramune	0	0	4	0	10	6	3	7	2	8	1	1
2	Chu et al. 1992b	bacterin	bacterin	bacterin	1ml 	<18 months	adult	no	needle	yes	LymeVax/Duramune	0	0	3	0	10	2	1	4	1	6	2	1
3	Chu et al. 1992c	bacterin	bacterin	bacterin	fractional dose	10-13 weeks	young	yes	needle	yes	LymeVax/Duramune	1	0	7	0	10	7	4	9	2	10	3	1
4	Chang et al. 1995a	recombinant OspA	recombinant	recombinant	100µg	6 weeks	young	no	ticks	unclear	component of Recombitek Lyme?	0	0			8	0	0			8	4	2
5	Chang et al. 1995b	recombinant OspA	recombinant	recombinant	10µg	6 weeks	young	no	ticks	unclear	component of Recombitek Lyme?	0	0			4	0	0			2	5	2
6	Chang et al. 1995c	recombinant OspA	recombinant	recombinant	100µg	6 weeks	young	no	ticks	unclear	component of Recombitek Lyme?	0	0			8	0	0			3	6	2
7	Coughlin et al. 1995	recombinant OspA and OspB	recombinant	recombinant	25µg each	12 weeks	young	no	ticks	no?		0		0	0	11	1		1	6	11	7	3
8	Straubinger et al. 1995a	recombinant OspA	recombinant	recombinant	100µg	6 weeks	young	no	ticks	unclear		0				18	26				46	8	4
9	Straubinger et al. 1995b	recombinant OspA	recombinant	recombinant	10µg	6 weeks	young	no	ticks	unclear		0				4	26				46	8	4
10	Ma et al. 1996	recombinant OspA and OspB	recombinant	recombinant	25µg each	12 weeks	young	no	ticks	no?		0				10	5				10	9	5
11	Straubinger et al. 2002a	recombinant OspA	recombinant	recombinant	?	8-10 weeks	young	no	ticks	yes	Recombitek Lyme	0				2	0				2	10	6
12	Straubinger et al. 2002b	multiantigenic bacterin	bacterin	bacterin	1ml	8-10 weeks	young	no	ticks	no?		0				6	0				2	10	6
13	Straubinger et al. 2002c	multiantigenic bacterin	bacterin	bacterin	1ml	8-10 weeks	young	no	needle	no?		0				2	0				2	10	6
14	Wikle et al. 2006	recombinant OspA	recombinant	recombinant	1ml 	9-12 weeks	young	no	ticks	yes	Recombitek Lyme	0	0	0	0	20	2	0	0	0	11	11	7
15	LaFleur et al. 2009	bivalent bacterin	bacterin	bacterin	1ml	8 weeks	young	some	ticks	yes	Nobivac Lyme	2				15	4				15	12	8
16	LaFleur et al. 2010	bivalent bacterin	bacterin	bacterin	1ml	8 weeks	young	yes	ticks	yes	Nobivac Lyme 	0				15	2				15	13	9
17	Ball 2015	chimeric recombinant	chimeric	recombinant	1ml 	8-9 weeks	young	no	ticks	yes	Vanguard crLyme	0				16	3				16	14	10
18	LaFleur et al. 2015	bacterin	bacterin	bacterin	1ml 	8 weeks	young	yes	ticks	component	Component of Nobivac Lyme	1				10	3				10	15	11
19	Grosenbaugh et al. 2016	recombinant OspA	recombinant	recombinant	1ml 	7-8 months	adult	no	ticks	yes	Recombitek Lyme	0			0	15	0			0	15	16	12