[R-sig-genetics] simulation of consanguineous unions in human populations with R

[Hinda Haned]

Dear list members,

I was wondering if anyone had experience simulating non-random mating 
human populations with R.

I want  to simulate the evolution of disease susceptibility loci under certain evolutionary scenarios and under specific non-random mating schemes. 
For example, at each generation, p% of the matings occur between first cousins, offspring from such unions (must) have on average 
1/16 of their genome autozygous.
I've been  exploring  simulation softwares  for a while , but they  offer limited  mating schemes, mainly because relationships between individuals can not be extracted.
Any ideas or suggestions are welcome !
Thank you .







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Hinda HANED
CNRS UMR 5558 - Laboratoire de Biométrie et Biologie Evolutive
Universite Lyon 1
43 bd du 11 novembre 1918
69622 Villeurbanne Cedex
Tél. : 04.72.43.27.57
Fax : 04.72.43.13.88
haned at biomserv.univ-lyon1.fr
http://lbbe.univ-lyon1.fr/-Haned-Hinda-.html?lang=en