[BioC] help with normalization
Richard Friedman
friedman at cancercenter.columbia.edu
Mon Sep 20 21:52:49 CEST 2010
Dear Caspyr,
All as one group.
Best wishes,
Rich
On Sep 20, 2010, at 3:50 PM, Casper Shyr wrote:
>
> Hello BioC,
>
> I have a quick question about the proper way to normalize arrays
> using gcrma. Right now I have a time series array, basically 10
> groups in total, each group has 2 replicates. The groups refer to
> time 0 (control), time 1,2,4,6,10,12...etc.
>
> When I normalize these cel files, should I normalize them together
> as one group, or should I perform separate normalizations on each of
> the groups (i.e. perform 10 separate normalizations on each of the
> 10 groups)?
>
>
>
> Thank you!
>
> Sincerely,
>
> Casper
>
> [[alternative HTML version deleted]]
>
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