[BioC] Analysing expression with tiling arrays

January Weiner january.weiner at mpiib-berlin.mpg.de
Tue Sep 14 16:35:16 CEST 2010

> this sounds reasonable, just be aware that the noise in the data from
> neighbouring probes is likely correlated, so that the t-distribution with
> the 'naive' degrees of freedom will give you optimistic (too small)
> p-values. You can still use them for ranking / prioritizing genes, and
> perhaps set the cutoff from known positive and negative control genes.

Thanks for the answer, Wolfgang. I did the simple / naive t-test, and
it still gave "reasonable" results (i.e. same as with a different



-------- Dr. January Weiner 3 --------------------------------------
Max Planck Institute for Infection Biology
Charitéplatz 1
D-10117 Berlin, Germany
Web   : www.mpiib-berlin.mpg.de
Tel     : +49-30-28460514

I di

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