[BioC] Analysis Question

[Lucia García]

Good morning,

 I have a doubt about the microarrays analysis (Affymetrix). After obtaining the signal data with RMA, these they are in base log2. My question is the following one: If I have 3 replycates, is it convenient to calculate Fold Change starting from the stocking of these sign values in log2, and did the one also p-value with these values in log2, or however it is better to work with the data in natural scale.? Thank you, Sorry for my english.

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