[BioC] Oneclass SAM analysis

[Brooke-Powell, Elizabeth]

Dear list,

I am wondering if you would be able help me with a problem I seem to be
experiencing using SAM (v2.20a). I am using it through the Excel add-in, but
the question I have is not a technical computer or programming problem (to
my knowledge) but one about the analysis itself. 

When I am performing oneclass analysis of ratio data from a microarray
experiment it seems that the oneclass analysis only likes to have odd
numbers of data columns where each data column is a list of ratios for one
slide in an experiment. I can get analysis done for 3,5,7,9,and 11 slides of
data, but not 2,4,6,8,10 or 12. I am wondering if I am missing something
about oneclass analysis, but it seems to me that you would want a balanced
design of an experiment with even numbers of slides.

Any help would be appreciated, I have tried contacting the SAM list which is
next to useless. 

Happy New Year to everyone,

Liz Brooke-Powell

Washington University Medical School, 
Department of Molecular Microbiology,
CB#8230, 660 S. Euclid Ave
St. Louis, MO, 63110