[BioC] flat microarray p-values

Sean Davis sdavis2 at mail.nih.gov
Thu Jun 1 22:10:14 CEST 2006

On 6/1/06 3:02 PM, "Darren Ames" <ames at Ag.arizona.edu> wrote:

> Hi Sean,
> Thanks for the reply. Upon closer inspection of the data, it appears that
> the qvalue package is working, but the output is just wonky. I get numbers
> that are the same value near 1 for all genes for most of my comparisons. The
> B-statistic is also a negative value. Could there be something in the gpr
> file that is causing this to occur?

All of this points to a lack of evidence for differential expression.
Perhaps n is too small (lack of power) or there is no differential
expression between groups.


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