[BioC] Predicting number of replicates

[Adaikalavan Ramasamy]

Err, what are your objectives here ? Is it to do sample size
calculations or simply wanting to have data to publish it.


 
On Wed, 2006-04-12 at 17:14 -0400, Khan, Sohail wrote:
> Dear List,
> 
> I have a basic statistical question regarding a Microarray data set.  However, I am not an statistician.  I was told the following problem can be modeled in R/ S_PLUS.
> 
> I have a data set with 3 replicates for the control and 3 replicates for experimental samples for a particular experiment.  I performed a t.test and adjusted the p. values for the false discovery rate.  Choosing a p value < 0.05, I didn't see any significant difference between the control and the experimental samples.  My question is how can I take the existing data and sort of 'simulate" (add data points) so that the adjusted p values become significant (< 0.05). The data is follows:
> 
> C.1	C.2	C.3	E.1	E.2	E.3
> 9.33	8.97	9.03	10.12	9.84	9.65
> 7.35	6.98	7.14	8.36	9.30	9.02
> ......	.......	........	........	.......	.....	
> .......	.......	........	........	.......	......
> 
> I thank you for any suggestions/advice...............any insight into this  would be a great learning experience for me.
> 
> 
> Sohail Khan
> Scientific Programmer
> COLD SPRING HARBOR LABORATORY
> Genome Research Center
> 500 Sunnyside Boulevard
> Woodbury, NY 11797
> (516)422-4076
> 
> _______________________________________________
> Bioconductor mailing list
> Bioconductor at stat.math.ethz.ch
> https://stat.ethz.ch/mailman/listinfo/bioconductor
> Search the archives: http://news.gmane.org/gmane.science.biology.informatics.conductor
>