[Statlist] Next talk: February 26, 2010 with Sach Mukherjee, University of Warwick

[Susanne Kaiser-Heinzmann]

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ETH and University of Zurich

Proff. A.D. Barbour - P. Buehlmann -  L. Held -
H.R. Kuensch - M. Maathuis - W. Stahel - S. van de Geer


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We are glad to announce the following talk

*Friday, February 26, 2010 15.15 - 17.00  HG  G 19.1 *
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with Sach Mukherjee, University of Warwick

Title:

Graphical modelling for cancer signalling

Abstract:

Networks of proteins called "signalling networks" play a key role in the 
control of diverse cellular processes; their aberrant functioning is 
heavily implicated in many diseases, including cancer. Aberrations in 
cancer cells are thought to perturb the normal connectivity of these 
networks, with important biological and therapeutic implications. Yet 
cancer-specific signalling remains poorly understood, especially at the 
level of relevant (post-translational) protein modifications. However, 
modern high-throughput biochemical technologies are now able to make 
measurements on components of these systems, and can, in principle, shed 
light on a variety of open questions concerning signalling in cancer. I 
will discuss statistical approaches for interpreting these data, in 
particular how graphical models can be used to integrate biochemical 
data and prior knowledge of signalling biology to facilitate the 
discovery process.
This abstract is also to be found under the following link:
http://stat.ethz.ch/talks/research_seminar

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