[R-meta] Fwd: Question on Umbrella review and other types

Thu Apr 25 10:05:39 CEST 2024

Dear Dr Gerta and Dr Michael!
Sorry to bother You again.

There is one concern. The two systematic reviews have come to almost same
main conclusion that young patients have higher chances of recurrence, and
few other findings. However, one conclusion is quite definite and second is
not much definite. Do You think it will be Ok to do the SRMA with inclusion
of additional studies in previous studies ? And also I would need to
register the study in PROSPERO as usual.

My boss was thinking earlier of having  a review study on
previously published studies, how that sounds ?

best regards,
Imran

On Wed, Apr 24, 2024 at 10:55 AM Im <aligners79 using gmail.com> wrote:

>
> Dear Dr Gerta!
>
> Thanks a lot for your much valuable suggestions, I will proceed
> accordingly.
>
> best regards,
> Imran
>
> On Tue, Apr 23, 2024 at 12:53 PM Dr. Gerta Rücker <
> gerta.ruecker using uniklinik-freiburg.de> wrote:
>
>> Dear Imran,
>>
>> On https://cran.r-project.org/web/packages/meta/index.html
>> (Documentation) you find links to the help file of the R package meta
>> (meta.pdf) and to a very basic tutorial. The help file contains help for
>> all functions, particularly metareg.meta() or briefly metareg() that is a
>> wrapper function of rma.uni() from the R package metafor. You find there an
>> example of a metaregression. Or type
>>
>> help(package = "meta")
>>
>> to get the online help. Of course, you can also use the metafor package
>> directly.
>>
>> Best,
>> Gerta
>>
>>
>> UNIVERSITÄTSKLINIKUM FREIBURG
>> Institute for Medical Biometry and Statistics
>>
>> Dr. Gerta Rücker
>> Guest Scientist
>>
>> Stefan-Meier-Straße 26 · 79104 Freiburg
>> gerta.ruecker using uniklinik-freiburg.de
>>
>> https://www.uniklinik-freiburg.de/imbi-en/employees.html?imbiuser=ruecker
>>
>> -----Ursprüngliche Nachricht-----
>> Von: Im via R-sig-meta-analysis <r-sig-meta-analysis using r-project.org>
>> Gesendet: Dienstag, 23. April 2024 09:44
>> An: Dr. Gerta Rücker <gerta.ruecker using uniklinik-freiburg.de>
>> Cc: Im <aligners79 using gmail.com>; R Special Interest Group for
>> Meta-Analysis <r-sig-meta-analysis using r-project.org>
>> Betreff: Re: [R-meta] Fwd: Question on Umbrella review and other types
>>
>> Hello Dr Gerta!
>> Thanks for your valuable suggestion.
>>
>> Could You please share with me the R codes, package for metaregression,
>> and
>> a brief method if I need to do this analysis ?
>>
>> I would be much grateful.
>> best regards,
>> Imran
>>
>> On Mon, Apr 22, 2024 at 10:43 PM Dr. Gerta Rücker <
>> gerta.ruecker using uniklinik-freiburg.de> wrote:
>>
>> > Hi Imran,
>> >
>> > I think the publication of new studies justifies an updated review,
>> > particularly if the existing reviews have inconsistent or inconclusive
>> > results.
>> >
>> > You should, however, avoid to be selective with the studies, let alone
>> > selective based on the results! This would be publication bias. What you
>> > can do if you suppose there is a time effect is a metaregression with
>> "year
>> > published" as a covariate.
>> >
>> > Best,
>> > Gerta
>> >
>> >
>> > UNIVERSITÄTSKLINIKUM FREIBURG
>> > Institute for Medical Biometry and Statistics
>> >
>> > Dr. Gerta Rücker
>> > Guest Scientist
>> >
>> > Stefan-Meier-Straße 26 · 79104 Freiburg
>> > gerta.ruecker using uniklinik-freiburg.de
>> >
>> >
>> https://www.uniklinik-freiburg.de/imbi-en/employees.html?imbiuser=ruecker
>> >
>> >
>> > -----Ursprüngliche Nachricht-----
>> > Von: Im via R-sig-meta-analysis <r-sig-meta-analysis using r-project.org>
>> > Gesendet: Montag, 22. April 2024 20:46
>> > An: R Special Interest Group for Meta-Analysis <
>> > r-sig-meta-analysis using r-project.org>
>> > Cc: Im <aligners79 using gmail.com>
>> > Betreff: Re: [R-meta] Fwd: Question on Umbrella review and other types
>> >
>> > Dear All!
>> > Many thanks indeed for your much valuable replies.
>> >
>> > My research is based on "Prognosis in relation to age in a carcinoma".
>> > The study results are "young age patients have better prognosis", "old
>> age
>> > have worst prognosis", "age has not affect on prognostication" etc....
>> > Is it possible to be selective in the studies in terms of time of
>> studies
>> > published etc., so that there can be some change in the analysis
>> > than previous ones ?
>> >
>> > With such a trivial number (only two) of previous SRMA, it seems better
>> to
>> > conduct a new SRMA instead. But I am bit concerned whether it is Ok
>> > to conduct a new SRMA when the previously SRMA have been published with
>> a
>> > gap of just couple of years (2020 and 2021)?
>> >
>> > So, if there is no problem in conducting a new SRMA, then I would be add
>> > the studies and proceed with the routine "meta" package in R studios for
>> > forest plots and funnel plots ?
>> >
>> > best regards,
>> > Imran
>> >
>> > On Mon, Apr 22, 2024 at 6:35 PM Dr. Gerta Rücker via
>> R-sig-meta-analysis <
>> > r-sig-meta-analysis using r-project.org> wrote:
>> >
>> > > Yes,I have noted that the word "umbrella" has experienced a change of
>> > > meaning over the last years. In former times (that is, before network
>> > > meta-analysis became popular) it meant to conduct a number of pairwise
>> > > meta-analyses for different treatments for the same condition in the
>> same
>> > > review. Since this is now better done using network meta-analysis,
>> they
>> > now
>> > > use the term for something different, namely overview of overviews,
>> and
>> > > this is what the original poster meant.
>> > >
>> > > As I understand, in the described situation, a re-analysis is planned,
>> > > thus I am not sure whether a special R package is needed.
>> > >
>> > > Best,
>> > > Gerta
>> > >
>> > > UNIVERSITÄTSKLINIKUM FREIBURG
>> > > Institute for Medical Biometry and Statistics
>> > >
>> > > Dr. Gerta Rücker
>> > > Guest Scientist
>> > >
>> > > Stefan-Meier-Straße 26 · 79104 Freiburg
>> > > gerta.ruecker using uniklinik-freiburg.de
>> > >
>> > >
>> >
>> https://www.uniklinik-freiburg.de/imbi-en/employees.html?imbiuser=ruecker
>> > >
>> > >
>> > > -----Ursprüngliche Nachricht-----
>> > > Von: Michael Dewey <lists using dewey.myzen.co.uk>
>> > > Gesendet: Montag, 22. April 2024 17:23
>> > > An: R Special Interest Group for Meta-Analysis <
>> > > r-sig-meta-analysis using r-project.org>
>> > > Cc: Dr. Gerta Rücker <gerta.ruecker using uniklinik-freiburg.de>
>> > > Betreff: Re: [R-meta] Fwd: Question on Umbrella review and other types
>> > >
>> > > There is a package https://cran.r-project.org/package=metaumbrella on
>> > > CRAN which performs umbrella reviews. Whether what they mean by
>> umbrella
>> > > is what you mean is open to question.
>> > >
>> > > Michael
>> > >
>> > > On 22/04/2024 15:44, Dr. Gerta Rücker via R-sig-meta-analysis wrote:
>> > > > Hi (whoever you are),
>> > > >
>> > > > If you want to repeat the old meta-analysis anyway, assuming that
>> all
>> > > studies adhere to some common well-defined inclusion criteria,  then
>> why
>> > > not conducting a meta-analysis including the union of all studies
>> > included
>> > > in the two older reviews and the new studies? This would simply be an
>> > > updated review, not necessarily an umbrella review.
>> > > >
>> > > > Best,
>> > > > Gerta
>> > > >
>> > > >
>> > > > UNIVERSITÄTSKLINIKUM FREIBURG
>> > > > Institute for Medical Biometry and Statistics
>> > > >
>> > > > Dr. Gerta Rücker
>> > > > Guest Scientist
>> > > >
>> > > > Stefan-Meier-Straße 26 · 79104 Freiburg
>> > > > gerta.ruecker using uniklinik-freiburg.de
>> > > >
>> > > >
>> > >
>> >
>> https://www.uniklinik-freiburg.de/imbi-en/employees.html?imbiuser=ruecker
>> > > >
>> > > > -----Ursprüngliche Nachricht-----
>> > > > Von: Im via R-sig-meta-analysis <r-sig-meta-analysis using r-project.org>
>> > > > Gesendet: Montag, 22. April 2024 15:47
>> > > > An: r-sig-meta-analysis using r-project.org
>> > > > Cc: Im <aligners79 using gmail.com>
>> > > > Betreff: [R-meta] Fwd: Question on Umbrella review and other types
>> > > >
>> > > > ---------- Forwarded message ---------
>> > > > From: Im <aligners79 using gmail.com>
>> > > > Date: Mon, Apr 22, 2024 at 12:56 PM
>> > > > Subject: Question on Umbrella review and other types
>> > > > To: <r-sig-meta-analysis using r-project.org>
>> > > >
>> > > >
>> > > >
>> > > > Hello!
>> > > >   I am planning to do an Umbrella review.
>> > > >
>> > > > The number of systematic/meta analysis are two. Rest of the studies
>> are
>> > > 3-4
>> > > > new studies published after or almost at same time of these two
>> > reviews.
>> > > >
>> > > > My question is can I conduct the Umbrella review ? If not then is
>> there
>> > > any
>> > > > other type of review that could be performed ?  I want to include
>> the
>> > > > previous systematic/meta reviews. I also plan to repeat already
>> > performed
>> > > > meta-analysis. Can I add the meta analysis studies HRs and new
>> studies
>> > to
>> > > > make another meta-analysis ?
>> > > >
>> > > > Please guide me which review could be the best in this situation.
>> > > > best regards
>> > > >
>> > > >       [[alternative HTML version deleted]]
>> > > >
>> > > > _______________________________________________
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>> > > >
>> > > >
>> > >
>> > > --
>> > > Michael
>> > > _______________________________________________
>> > > R-sig-meta-analysis mailing list @ R-sig-meta-analysis using r-project.org
>> > > To manage your subscription to this mailing list, go to:
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>> > >
>> >
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>> >
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