[R-meta] Three-level meta-analysis using netmeta

Natan Gosmann n@t@n@go@m@nn @end|ng |rom gm@||@com
Mon Mar 22 08:28:15 CET 2021

Many thanks, Wolfgang!
We are also performing meta-regression analyses using this three-level
network approach, so, as you mentioned, this is a major advantage of using
metafor on this project. Your comments were really helpful!


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Em qua., 17 de mar. de 2021 às 09:39, Viechtbauer, Wolfgang (SP) <
wolfgang.viechtbauer using maastrichtuniversity.nl> escreveu:

> Dear Natan,
> Gerta, Guido, and colleagues (i.e., the netmeta authors) should really be
> the ones to address your question about netmeta. But I am once again
> procrastinating with my own work by answering questions on this mailing
> list and once I get going, I am hard to stop, so let me say just a few
> words about this.
> netmeta is indeed a very nice choice for a network meta-analysis as it
> simplifies some of the intricacies involved, compared to the more manual
> process required when fitting such models with metafor. However, you can
> run network meta-analyses also with metafor, if you know how to set things
> up (and are willing to do a bit of 'post-processing' of the results). So
> that is the disadvantage of using metafor for these purposes. The advantage
> is that it will allow you to expand on the underlying models in essentially
> arbitrary ways, including the addition of additional levels and/or random
> effects to capture further dependencies. Also, one can run meta-regression
> analyses in this context, which I believe is not (yet) possible with
> netmeta (although this is something that may be in the works?).
> If the more complex data structure in the present context require the
> specification of corresponding models, then I do not see why using metafor
> is actually a problem; quite the opposite.
> Best,
> Wolfgang
> >-----Original Message-----
> >From: R-sig-meta-analysis [mailto:
> r-sig-meta-analysis-bounces using r-project.org] On
> >Behalf Of Natan Gosmann
> >Sent: Wednesday, 17 March, 2021 9:25
> >To: r-sig-meta-analysis using r-project.org
> >Subject: [R-meta] Three-level meta-analysis using netmeta
> >
> >Dear all,
> >
> >Our group recently submitted for publication a three-level network
> >meta-analysis that was sent to peer review and one aspect of concern that
> >was raised during the review process is the fact that we performed our
> data
> >analysis using metafor (through methods described by Wolfgang elsewhere).
> >Reviewers stated that moving to netmeta might be preferable, given that it
> >is specifically designed for network meta-analyses. Although we recognize
> >the great value of netmeta for network meta-analyses, we are not sure that
> >currently the package is able to perform three-level meta-analyses (even
> >after carefully reading its detailed manual). Can we perform our data
> >analysis (using the three-level/network approach) using netmeta? If yes,
> >any suggestion or reference with any guidance on how to do it would be of
> >great help.
> >
> >Best,
> >Natan Gosmann

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