[R-meta] Meta-Analysis: Proportion in overall survival rate
neg|c4 @end|ng |rom gm@||@com
Tue May 19 15:00:13 CEST 2020
Thank you for your reply.
Correct, I want to pool survival proportions (single-arm), not hazard
ratios (comparing two arms).
But you raise some important points and I shall first have to re-evaluate
each study to see if they all adjusted for covariates, and which.
In case of further questions after re-checking them, I shall respond to
On Tue, May 19, 2020 at 2:32 PM Gerta Ruecker <ruecker using imbi.uni-freiburg.de>
> Dear Nelly,
> You could do this, at least in principle, if all proportions refer to
> the same timepoint, for example 5 years. The problem is that the data
> you obtain from studies with a time-to-event endpoint are different from
> those that directly provide a five-year survival proportion: The
> time-to-event analysis accounts for censoring, while the proportion of
> living after five years relatively to all patients at baseline usually
> does not account for censoring or missing data (and thus may
> underestimate the true proportion).
> If I understand you correctly, you want to pool survival proportions
> (single-arm), not hazard ratios (comparing two arms).
> The technical thing is that you have survival proportions with standard
> error from the time-to-event studies and single proportions (survived/n)
> from other studies. Survival proportions with standard errors can be
> pooled usingthe generic inverse variance method. Proportions are best
> be pooled using generalized linear models. See, for example, the
> examples for function metaprop() in R package meta.
> Am 19.05.2020 um 14:15 schrieb ne gic:
> > Dear List,
> > From time to event data, it's common to calculate a combined HR for
> > instance from included studies - this I understand.
> > Does it make sense to perform a meta-analysis of the proportion (%) one
> > gets from overall time survival e.g. Overall 5y survival? imagine a
> > scenario where different studies are reporting different proportions of
> > patients surviving at this time point and I want to report a summary
> > proportion from all the studies at this time point.
> > If this is possible, does just collecting the proportion at that time
> > e.g. 5 year suffice as the data to use for this calculation? Or what
> > you suggest? Haven't seen a package that just takes a proportion.
> > Sincerely,
> > nelly
> > [[alternative HTML version deleted]]
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> Dr. rer. nat. Gerta Rücker, Dipl.-Math.
> Institute of Medical Biometry and Statistics,
> Faculty of Medicine and Medical Center - University of Freiburg
> Stefan-Meier-Str. 26, D-79104 Freiburg, Germany
> Phone: +49/761/203-6673
> Fax: +49/761/203-6680
> Mail: ruecker using imbi.uni-freiburg.de
> Homepage: https://www.uniklinik-freiburg.de/imbi.html
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