[R-meta] Meta analysis on means and standard deviation

[m@@o@berger@t m@iii@g oii gm@ii@com]

Dear Meta-analysis community,

We are performing a meta-analysis on means and we have some questions about the package metafor. 
Our dataset includes means, standard deviations, the year of measure, and the age of our population.

The code for our meta regression is : 
meta= rma.uni(yi = M, vi = variance, weights = 1/variance, method="REML", mods=~1+Year+Age, data=table)

1: We would like to estimate an adjusted pooled variance. 
For the moment, we have succeed to obtain an adjusted pooled mean. But for the variance, can we take into account the value in the variance-covariance matrix (« vb ») as a result of an adjusted pooled variance?

2: We categorized the variable « year » and we would like to have a global p-value of this categorized value.
Is the function in « Anova » anova(meta, btt = 2:4) correct to obtain this global p-value? 
And is it adjusted related to our other variable « age » ?

Is it possible to have a p-value for trend? 

3: Is the « lsmeans »  package compatible with metafor? 

Thank you in advance. 

Best regards. 

Manon Bergerat 
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