[R-meta] Combine HR from multiple groups?

[Gerta Ruecker]

Dear Kathrin, dear all,

you may have a look into Rücker G, Cates CJ, Schwarzer G. Methods for 
including information from multi‐arm trials in pairwise meta‐analysis. 
/Res Syn Meth/. 2017;8:392–403. https://doi.org/10.1002/jrsm.1259

In Table 3 there you find an example very similar to yours. Methods to 
pool these data are given in subsection 4.2, with results presented in 
Figures 9 (approximate adjustment) and 10 (exact adjustment) of this paper.

If you don't have access to the article or need further information, 
please ask.

Kind regards,

Gerta


Am 21.02.2019 um 15:17 schrieb Kathrin Kuhr:
> Hi all,
>
> our situation: In a network meta-analysis, we want to pool two nodes 
> (two doses of the same treatment). Outcome of interest is overall 
> survival (Hazard ratios). To include a three-arm study (arm A: 
> treatment dose A; arm B: treatment dose B, arm C: placebo), we have to 
> combine the two treament arms. We only have relative treatment effect, 
> i.e. HR A vs. B, HR A vs. C, HR B vs. C. Is there a possibility to 
> pool HR A vs. C and B vs. C? As we use the same comparator C, we 
> cannot easily calculate a pooled meta-analysis estimate, right? And as 
> we only have relative effects, we cannot easily pool arm A and B as 
> for binary data or mean values, right? Or do we think too complicated?
>
> We are happy for any ideas or examples.
>
> Thanks,
>
> Kathrin and Anne
>
-- 

Dr. rer. nat. Gerta Rücker, Dipl.-Math.

Institute of Medical Biometry and Statistics,
Faculty of Medicine and Medical Center - University of Freiburg

Stefan-Meier-Str. 26, D-79104 Freiburg, Germany

Phone:    +49/761/203-6673
Fax:      +49/761/203-6680
Mail:     ruecker using imbi.uni-freiburg.de
Homepage: https://www.imbi.uni-freiburg.de/persons/ruecker/person_view


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