[R-meta] funnel plot(mixed-effect model) and the assumption of normality

[Angeline Tsui]

Hello all,

I have two questions about my meta-analysis and I wonder if you can answer
the following:

1) When plotting a funnel plot, I want to control for predictors that may
explain the relationship between effect size and standard error and I
suspect that this relationship can partially be explained by moderators in
my meta-regression model. So I plotted my funnel plot based on a
mixed-effect meta-regression model. However, I do not fully understand what
I was plotting here. When I plot my funnel plot based on mixed-effect
model, does it mean that I am plotting the relationship between predicted
effect size of the mixed-effect model and standard error. Or am I plotting
the relationship between the residual values of the model and the standard
error.

2) For normality assumption, my teacher said that it is important to ensure
the effect sizes across studies in the meta-analysis and the moderators are
normally distributed. Is this true? I was wondering if the normality
assumption is actually restricting the residual of the meta-regression
model (fixed/random-effect) to be normally distributed, not the effect
sizes and moderators? Furthermore, is the model (fixed/random-effect)
robust for mild or moderate violation of the normality assumption? Can
someone suggest some references for me to read for this specific topic?

Thank you,
Angeline


-- 
Best Regards,
Angeline

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