If you don't want X11 and you don't want ATLAS configure --with-tcl-config=/Library/Frameworks/Tcl.framework/tclConfig.sh --with-tk-config=/Library/Frameworks/Tk.framework/tkConfig.sh --without-x --enable-R-shlib --with-blas='-framework vecLib' --with-lapack --with-aqua TCLTK_LIBS='-framework Tcl -framework Tk' TCLTK_CPPFLAGS='-framework Tcl -framework Tk'