[R-sig-dyn-mod] Fitting ODE and DDE models with FME using missing data

[Nicola Gambaro]

Dear all,

I have to estimate some unknown parameters of an ODE/DDE model. However, we only have access to data of some but not all state variables. Also, some state variable data may have observational gaps in between the time series.

Is there a way to at least approximately fit the model with FME? If not, could anyone point me to alternative packages or relevant algorithms?

Many thanks,
Nicola