On Tue, 25 Oct 2022 08:33:10 -0500 ken eagle <eaglek2011 using gmail.com> wrote: > I thought I was loading a ~300M binary (bigwig) file into another > application . . . Is the other application R dependent, written in R, or call R capacities? If it doesn't, the issue might be with the "other application rather than R. JWDougherty