[R] Nonlinear logistic regression fitting

[Sebastien Bihorel]

I hardly see how your reply addressed my question or any part of it. It looks to me that it was simply assumed that I did not perform any search before posting.

________________________________
From: Bert Gunter <bgunter.4567 using gmail.com>
Sent: Tuesday, July 28, 2020 11:30
To: Sebastien Bihorel <Sebastien.Bihorel using cognigencorp.com>
Cc: r-help using r-project.org <r-help using r-project.org>
Subject: Re: [R] Nonlinear logistic regression fitting

You said:
"As far as I know (please, correct me if I am wrong), fitting such a model is to not doable with glm, since the function is not linear."

My reply responded to that.

AFAIK, opinions on packages are off topic here. Try stats.stackexchange.com<http://stats.stackexchange.com> for that.

Bert Gunter

"The trouble with having an open mind is that people keep coming along and sticking things into it."
-- Opus (aka Berkeley Breathed in his "Bloom County" comic strip )


On Tue, Jul 28, 2020 at 8:19 AM Sebastien Bihorel <Sebastien.Bihorel using cognigencorp.com<mailto:Sebastien.Bihorel using cognigencorp.com>> wrote:
Thank you for your subtle input, Bert... as usual!

This is literally the search I conducted and spent 2 hours on before posting to R-help. I was asking for expert opinions, not for search engine FAQ!

Thank anyways

________________________________
From: Bert Gunter <bgunter.4567 using gmail.com<mailto:bgunter.4567 using gmail.com>>
Sent: Tuesday, July 28, 2020 11:12
To: Sebastien Bihorel <Sebastien.Bihorel using cognigencorp.com<mailto:Sebastien.Bihorel using cognigencorp.com>>
Cc: r-help using r-project.org<mailto:r-help using r-project.org> <r-help using r-project.org<mailto:r-help using r-project.org>>
Subject: Re: [R] Nonlinear logistic regression fitting

Search!
... for "nonlinear logistic regression" at rseek.org<http://rseek.org>.

Bert Gunter

"The trouble with having an open mind is that people keep coming along and sticking things into it."
-- Opus (aka Berkeley Breathed in his "Bloom County" comic strip )


On Tue, Jul 28, 2020 at 7:25 AM Sebastien Bihorel via R-help <r-help using r-project.org<mailto:r-help using r-project.org>> wrote:
Hi

I need to fit a logistic regression model using a saturable Michaelis-Menten function of my predictor x. The likelihood could be expressed as:

L = intercept + emax * x / (EC50+x)

Which I guess could be expressed as the following R model

~ emax*x/(ec50+x)

As far as I know (please, correct me if I am wrong), fitting such a model is to not doable with glm, since the function is not linear.

A Stackoverflow post recommends the bnlr function from the gnlm (https://stackoverflow.com/questions/45362548/nonlinear-logistic-regression-package-in-r)... I would be grateful for any opinion on this package or for any alternative recommendation of package/function.
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