[R] least square fit with non-negativity constraints for absorption spectra fitting

Xu, Xiuli (NIH/NHLBI) [E] xux3 at nhlbi.nih.gov
Wed Jul 12 00:12:32 CEST 2006

I would really appreciate it if someone can give suggestions on how to
do spectra fitting in R using ordinary least square fitting and
non-negativity constraints. The lm() function works well for ordinary
least square fitting, but how to specify non-negativity constraints? It
wouldn't make sense if the fitting coefficients coming out as negative
in absorption spectra deconvolution.



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