[R] a fit method for gls?

Gordon Smyth smyth at wehi.edu.au
Tue Jan 14 01:56:03 CET 2003

Dear all,

I make extensive use of the gls function from the nlme library for 
microarray data analysis (details described 
http://bioinf.wehi.edu.au/smawehi/library/smawehi/html/gls.series.html). A 
typical fit involves running gls about 15000 times with the same formula, 
with different reponses and weights but with the same design matrix. Is 
there a way to avoid parsing the same formula every time gls is called by 
giving gls the response vector, weights and design matrix directly? That 
is, is there some way to call gls which is analogous to lm.fit for lm or to 
glm.fit for glm?

Thanks for any suggestions
Dr Gordon K Smyth, Senior Research Scientist, Bioinformatics,
Walter and Eliza Hall Institute of Medical Research,
1G Royal Parade, Parkville, Vic 3050, Australia
Tel: (03) 9345 2326, Fax (03) 9347 0852,
Email: smyth at wehi.edu.au, www: http://www.statsci.org

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