[BioC] Combing Effects (t-stats) from experiment with common reference design?
atulkakrana at outlook.com
Thu Aug 28 21:52:47 CEST 2014
I was wondering whether there is any approach to combine 't-stat' from
different comparisons but using same control. These are my contrasts:
Stage1 vs ControlX
Stage2 vs ControlX
Stage3 vs. ControlX
Stage 20 vs. ControlX
Here the control is same i.e. same sample for all contrasts. From
'limma' analysis I have Fold change, t-stats and p-values for each gene.
Now, is it possible to combine 't-stats' from all different stages to
single value? Or compute a single combined value for all the contrasts.
So, that this single metric could be used to rank genes across all time
points. Is there any package available to do so? I can find methods to
combine p-values but not the 't-stat'.
[[alternative HTML version deleted]]
More information about the Bioconductor