[BioC] Homoscedasticity

[Tibor Pakozdi [guest]]

Hello,

Since ComBat was originally developed for microarray expression data where homoscedasticity was assumed, do we first need to convert heteroscedastic data such as the ones from NGS experiments into homoscedastic (e.g. by DESeq's VST) or the method can deal with samples of unequal variance?

Thanks.

 -- output of sessionInfo(): 

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