[BioC] RMA normalisation of test microarray data to training data

[Daniel Brewer]

Hello,

We have done some analysis on a set of Affy microarray data normalised by RMA and produced a predictor.  We would like to test this predictor on a training set we have.  Is it possible to RMA normalise the test dataset so that the probes have the same distribution as the training dataset without normalising all the data together?  Our concern is that if you normalise them all together then this would mean we would have to go through all the analyses again.

Thanks

Dan

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Daniel Brewer, Ph.D.

Institute of Cancer Research
Prostate Cancer Genome Team

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The Institute of Cancer Research: Royal Cancer Hospital, a charitable Company Limited by Guarantee, Registered in England under Company No. 534147 with its Registered Office at 123 Old Brompton Road, London SW7 3RP.

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