[BioC] Improvements on GCRMA function

[Zhijin Wu]

It has been updated.
Jean
Javier Pérez Florido wrote:
> Dear list,
> Some months ago, I read the following paper:
> http://bioinformatics.oxfordjournals.org/cgi/content/abstract/23/13/i282
> 
> It is said:"we identify a crucial step in GCRMA responsible for 
> introducing severe artifacts in the data leading to a systematic 
> overestimate of pairwise correlation. This has key implications not only 
> for reverse engineering but also for other methods, such as hierarchical 
> clustering, relying on accurate measurements of pairwise expression 
> profile correlation. We propose an alternative implementation to 
> eliminate such side effect".
> 
> I've checked the papers that reference this work, but no one is about 
> the improvement of GCRMA. Does anyone know if, after this paper was 
> published, GCRMA was fixed?
> 
> Thanks,
> Javier
> 
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-- 
------------------------------------
Zhijin (Jean) Wu
Assistant Professor of Biostatistics
Brown University, Box G-S121
Providence, RI  02912

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Fax: 401 863 9182
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