[BioC] microarray analysis in R without replicates

[Rainer Tischler]

Komplettansicht
Dear all,

I
have received a microarray data set in standard Affymetrix CEL-format
consisting of only six samples  without any replicates (same organism
and cell type, but different individuals and different biological
conditions for each individual; the same Affymetrix GeneChip platform
was used for all samples). Moreover, the data was apparently collected
without any a-priori biological hypothesis.

I know that it is
impossible to apply standard clustering, feature selection or
classification techniques in this case. However, I am wondering whether
anybody is aware of a method in R to extract meaningful biological
information in this case (i.e. from single-sample microarray data or
from multiple samples with different biological conditions and no
replicates) - or is there nothing I can do given the above limitations?

Many thanks,
Rainer