[BioC] Filtering before differential expression analysis of microarrays - New paper out

Daniel Brewer daniel.brewer at icr.ac.uk
Mon Jan 12 11:48:43 CET 2009


There is a new paper out at BMC bioinformatics that seems to justify the
use of filtering before differential expression analysis is performed
(Hackstadt & Hess BMC Bioinformatics 2009, 10:11 -
http://www.biomedcentral.com/1471-2105/10/11/abstract).  Specifically
filtering by variance and detection call.  I have got the impression
from this list that the general opinion is that one should only filter
out the control genes before testing.  I was wondering if anyone had any
opinions on this paper and the topic in general.

Many thanks


Daniel Brewer, Ph.D.

Institute of Cancer Research
Molecular Carcinogenesis
Email: daniel.brewer at icr.ac.uk

The Institute of Cancer Research: Royal Cancer Hospital, a charitable Company Limited by Guarantee, Registered in England under Company No. 534147 with its Registered Office at 123 Old Brompton Road, London SW7 3RP.

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