[BioC] Robust Spline Normalization (lumi) - illumina data matrix

Henrik Bengtsson hb at stat.berkeley.edu
Mon Jan 28 21:55:11 CET 2008


On Jan 28, 2008 7:04 AM, Sharon <sharonanandhi at gmail.com> wrote:
> Dear all,
> I have an illumina microarray data in a matrix form, ie. simply a AVG
> signal. Since I don't have detection p-values and STDERR values, it is
> difficult for me to make a lumi object. Is it possible to apply RSN on
> matrix format instead of lumi object?

I don't know the details (assumptions/model/algorithm) for the robust
spline normalization method you're referring to, but fyi there are
several bare-bone and rather generic calibration and normalization
methods that takes matrices and lists in the 'aroma.light' package.


> Thanks in advance.
> Kind regards,
> Sharon
>         [[alternative HTML version deleted]]
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