[BioC] combining p-values for multiple genes using stouffer

[william ritchie]

Dear Bioc community,


I have a little question about combining p-values with stouffers method.
One of the conditions for combining p-values is that each test be considered as independent.
If I was interested in a group of say, 10 genes and I wanted to know if, as a group, they were significantly over or under expressed, would it be correct to combine the p-values (calculated from a series of microarrays) for each individual gene using stouffers method to be able to conclude that this group of genes is differentially expressed ?
Thanks,
william.



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