[BioC] Problematic circular design

Daniel Brewer daniel.brewer at icr.ac.uk
Thu Sep 6 18:13:57 CEST 2007


I have just been handed a project that looks like the experimental
design has not been ideal and I was wondering if anyone had any ideas
how I could get something out of it.

Here is the design:
3 microarrays
Array 1: A vs B
Array 2: B vs C
Array 3: C vs A

Where A, B, C are different samples.

The question that the experimenter would like to ask is what are the
similarities between the three samples and what are the differences.
Has anyone got any bright ideas how to proceed?  Without a control I
can't really see how to do this.


Daniel Brewer, Ph.D.
Institute of Cancer Research
Email: daniel.brewer at icr.ac.uk

The Institute of Cancer Research: Royal Cancer Hospital, a charitable Company Limited by Guarantee, Registered in England under Company No. 534147 with its Registered Office at 123 Old Brompton Road, London SW7 3RP.

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