[BioC] RMA-bimodality:

Wolfgang Huber huber at ebi.ac.uk
Tue Jun 6 00:23:12 CEST 2006

Hi Noel,

> Just so that I am clear- the point is that the
> bimodality is not an artifact of the convolution, but
> simply the fact that the number of modes of a
> distribution is not conserved under monotonous
> transformations.

No, I did not say that, and I do not know how to understand this sentence,
since "the convolution" is directly related to "the monotonous
transformation" that we are talking about

> This is why the paper points to the
> fact that the histograms of log2 (PMs/MMs) stratified
> by log2(PMs) is bimodal

I leave the exegesis of the paper to its authors.

> -so bimodality is a more
> general property of the probe level data.

As you have just said yourself, the number of modes is not a property of
the data, but of the data plus the particular (non-linear) transformation
that you choose to apply to them.

Best wishes

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