[BioC] limma 2.2.0 - decideTests heirarch/nestedF + BH correction , small bug
Ariel Chernomoretz
ariel.chernomoretz at crchul.ulaval.ca
Wed Nov 23 16:55:20 CET 2005
Hi,
I think I found a small bug in decideTests
when heirarchical or nestedF methods are selected in conjunction with
adjust.method="BH" (the new default value).
In both cases there is a problem with the 'switch' command.
In adjust heirarchical:
51 a <- switch(adjust.method,
52 none=1,
53 bonferroni=1/n,
54 holm=1/(n-i+1),
55 BH,fdr=i/n <------- BH=i/n,fdr=i/n
56 )
In adjust nestedF:
65 a <- switch(adjust.method,
66 none=1,
67 bonferroni=1/n,
68 holm=1/(n-i+1),
69 fdr=i/n <------- BH=i/n,fdr=i/n
70 )
btw, the p.adjust function of statmod package makes no distinction between BH
and fdr methods, why introduce such distinction in limma? (or am I missing
something?)
regards, and thanks for an excellent tool!
Ariel./
--
Ariel Chernomoretz, Ph.D.
Centre de recherche du CHUL
2705 Blv Laurier, bloc T-367
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