[BioC] repeated measures in limma?

rob foxall (IFR) rob.foxall at bbsrc.ac.uk
Thu Nov 10 12:42:29 CET 2005


Hi,
	My problem is as follows: I have a bunch of subjects with a
medical condition, and a bunch of normals, and I am looking for
differences between the two groups. However, I have several arrays per
subject (biological replicates), and so would like to include subject
variability into the model. If this was a usual single-response problem,
I might use the package "nlme" from R, something like

fit <- lme(fixed=response ~ condition, data=mydata, random= ~1 |
Subject)

Is there something analogous to this in limma?

Cheers,
	Rob.



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