[BioC] Generic Loess Normalization

Wolfgang Huber huber at ebi.ac.uk
Fri Mar 4 17:03:33 CET 2005

Hi Gene,

for general local regression, you may also want to look at the locfit 
package (on CRAN) which one might call a faster and more advanced 
version of loess. It provides better diagnostic output and there is a 
very nice textbook going with it.

  Best wishes

James W. MacDonald wrote:
> Gene Cutler wrote:
>> Of the various Bioconductor methods, is there any which performs a 
>> fairly generic loess normalization, leaving out fancy stuff like 
>> print-tip normalization, etc?
>> I'd like to write some code based on this, so I'd like to see a 
>> stripped-down example if there is one out there.
> You might look at loessFit in the limma package. Much of the heavy 
> lifting appears to be done in C, however.
> Jim

Wolfgang Huber
European Bioinformatics Institute
European Molecular Biology Laboratory
Cambridge CB10 1SD
Phone: +44 1223 494642
Fax:   +44 1223 494486
Http:  www.ebi.ac.uk/huber

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