[BioC] Comparision of expression values from 4 different studies

[Margaret Gardiner-Garden]

Dear Srini,

Some meta-analysis references that might be of interest to you are:
1. "Combining multiple microarray studies and modeling interstudy
variation". JK Choi et al.(2003) Bioinformatics. Vol.19 Suppl.1 pg
i84-i90.
2. "Comparison and meta-analysis of microarray data: from the bench to
the computer desk". Y Moreau et al.(2003) Trends in
Genetics(19)10:570-577.
3. "Meta-analysis of microarrays: Interstudy validation of gene
expression profiles reveals pathway dysregulation in prostate cancer." D
Rhodes et al.(2002) Cancer Research 62: 4427-4433.
4. Differences in gene expression between B-cell chronic lymphocytic
leukemia and normal B cells: a meta-analysis of three microarray studies
J.Wang et al (2004) Bioinformatics 20: 3166-3178
5. Large-scale meta-analysis of cancer microarray data identifies common
transcriptional profiles of neoplastic transformation and progression D.R.
Rhodes et al (2004) PNAS 101:9309-9314
6. The rmeta Package in R (Thomas Lumley)


Regards,
Marg

Dr Margaret Gardiner-Garden
Garvan Institute of Medical Research
Sydney Australia



-----Original Message-----
From: bioconductor-bounces at stat.math.ethz.ch
[mailto:bioconductor-bounces at stat.math.ethz.ch]On Behalf Of Rafael
Irizarry
Sent: Monday, February 28, 2005 5:54 AM
To: Srinivas Iyyer
Cc: bioconductor at stat.math.ethz.ch
Subject: Re: [BioC] Comparision of expression values from 4 different
studies


what i did to combine data from 3 platofroms from 10 different labs is
described here:

http://www.bepress.com/jhubiostat/paper71/

-r
On Feb 27, 2005, at 1:44 PM, Srinivas Iyyer wrote:

> Dear group, I have 4 microarray studies.  I am
> interested in comparing the expression (expression
> values) of my genes across these studies.
>
> I want to take expession value of gene A from first
> study and and take expression values from other
> studies, and compare them. Is this process
> statistically allowed. or do i have to do some
> treatments for all 4 studes, to bring to a some level
> so that the expression values can be comparable. Is
> meta-analysis is the way to go? please suggest..
> thank you very much
> srini
>
> _______________________________________________
> Bioconductor mailing list
> Bioconductor at stat.math.ethz.ch
> https://stat.ethz.ch/mailman/listinfo/bioconductor

_______________________________________________
Bioconductor mailing list
Bioconductor at stat.math.ethz.ch
https://stat.ethz.ch/mailman/listinfo/bioconductor