[BioC] random block effect and technical replicates within array at the same in linear model using Limma ?

[Naomi Altman]

You could do this using LME.  It will be slow.

--Naomi

At 05:47 AM 6/2/2005, HAG wrote:
>Dear list,
>
>I have an experiment with 24 arrays.
>I have 3 factors each with 2 levels and 12 blocks (1,1,2,2,3,3,....,12,12).
>Each gene is replicated 4 times on each array.
>
>I know how to fit blocks as random as explained in the Limma manual 
>(Technical replication I)
>I know how to account for the replication within arrays.
>
>
>Is it possible to fit random block effect and technical replicates within 
>array at the same in linear model using Limma ?
>
>Thanks
>Peter
>
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Naomi S. Altman                                814-865-3791 (voice)
Associate Professor
Bioinformatics Consulting Center
Dept. of Statistics                              814-863-7114 (fax)
Penn State University                         814-865-1348 (Statistics)
University Park, PA 16802-2111