[BioC] random block effect and technical replicates within array at the same in linear model using Limma ?
naomi at stat.psu.edu
Sat Jul 9 18:15:05 CEST 2005
You could do this using LME. It will be slow.
At 05:47 AM 6/2/2005, HAG wrote:
>I have an experiment with 24 arrays.
>I have 3 factors each with 2 levels and 12 blocks (1,1,2,2,3,3,....,12,12).
>Each gene is replicated 4 times on each array.
>I know how to fit blocks as random as explained in the Limma manual
>(Technical replication I)
>I know how to account for the replication within arrays.
>Is it possible to fit random block effect and technical replicates within
>array at the same in linear model using Limma ?
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>Bioconductor at stat.math.ethz.ch
Naomi S. Altman 814-865-3791 (voice)
Bioinformatics Consulting Center
Dept. of Statistics 814-863-7114 (fax)
Penn State University 814-865-1348 (Statistics)
University Park, PA 16802-2111
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