[BioC] gcrma
Lana Schaffer
schaffer at scripps.edu
Wed Jan 5 21:55:33 CET 2005
Hi,
I have been reading the papers "A Model Based Background Adjustment for
Oligonucleotide Expression Arrays" and "Stochastic Models Inspired by
Hybridization theory for short Oligonucleotide Arrays" and comparing
these papers to the options available in Bioconductor for gcrma.
I request some clarification for the options: fullmodel, affinities,
mm, and constant. Does the fullmodel use the MLE or the Bayes estimate? Is
there some literature that compares the results of the various options to one
another, since the options don't seem to be exactly those presented in the
papers? I assume the mm option to use an unadjusted mm?
So would you say that gcrma still uses the mm's?
Thanks for your input.
Lana
Lana Schaffer
Research Specialist
The Scripps Research Institute
DNA Array Core Facility
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