[BioC] genes variances

Robert Gentleman rgentlem at fhcrc.org
Fri Apr 22 16:44:47 CEST 2005


Hmm, google will do most of that work for you, Wolfgang Huber has done  
a lot of work on this (see the package vsn, which contains code for  
carrying out such an analysis).

On Apr 22, 2005, at 5:12 AM, E Motakis, Mathematics wrote:

> Dear all,
>
> Recently, I have been working on variance stabilization techniques for  
> cDNA microarrays. I have been studying the papers:
>
> I. Rocke and Durbin, (2001), `A model for measurement error for gene  
> expression arrays', J. Comput. Biol, 8, 557--569 and
>
> II. Durbin, Hardin, Hawkins, and Rocke, (2002), `A  
> variance-stabilizing transformation for gene-expression microarray  
> data', Bioinformatics, 18, S105-S110.
>
> Their variance stabilization seems to work well for most of the genes  
> I replicate (and for my data). I wonder if someone is aware of other  
> related papers to that subject (not only by those authors). Is there  
> any other technique for variance stabilization available in the  
> microarrays literature?
>
> Thank you in advance.
>
> Makis Motakis
>
> ----------------------
> E Motakis, Mathematics
> E.Motakis at bristol.ac.uk
>
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> Bioconductor at stat.math.ethz.ch
> https://stat.ethz.ch/mailman/listinfo/bioconductor
>
>
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