[BioC] Questions about limma
He, Yiwen (NIH/CIT)
heyiwen at mail.nih.gov
Tue Apr 5 18:10:51 CEST 2005
Hi, I have some questions about the data that the limma package can work on.
If I have some preprocessed/normalized data of log2 ratios from 2-color
arrays, but not the raw signal data, can I still use lmFit? A related
question is, can limma work on a subset of the data from an array? For
example, after normalization, I filter out some probes/spots. If I can
retrieve the M and A values of that subset, can I still use limma?
Bottom line, do I always have to start with raw data while using limma?
Also, are there any test data available in the package?
Thank you, Yiwen
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Yiwen He, Ph.D., M.P.H.
Contractor, SRA International Inc.
Bioinformatics and Molecular Analysis Section
Center for Information Technology
National Institute of Health
Bldg. 12A, Rm. 1018
12 South Dr., Bethesda, MD 20892
Email: heyiwen at mail.nih.gov
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