[BioC] Control spots for global normalization

thama at imbb.forth.gr thama at imbb.forth.gr
Fri Jul 9 11:29:42 CEST 2004

Dear Christian,

The R package and the reference you want are genomics.sma R package (van 
Peppel et al,(2003) EMBO reports,Monitoring global messenger RNA changes in 
externally controlled microarray experiments). 


>From Christian Landry <clandry at fas.harvard.edu>:

> Hi All,
> Would any of you know any good reference where the use of control spots
> (positive controls for which we put equal amount of RNA or DNA in both
> channels) are used as a sole source for global or local normalization in
> cDNA microarrays? 
> I am particularly interested in the number needed and the statistical
> treatment that goes with them.
> Thanks a lot,
> Christian Landry
> ------( )--------
> Christian Landry
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