[BioC] Control spots for global normalization

[Christian Landry]

Hi All,

Would any of you know any good reference where the use of control spots
(positive controls for which we put equal amount of RNA or DNA in both
channels) are used as a sole source for global or local normalization in
cDNA microarrays? 

I am particularly interested in the number needed and the statistical
treatment that goes with them.


Thanks a lot,

Christian Landry
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Christian Landry